[Human red cell metabolism and its pathophysiology].
Nihon Rinsho
; 54(9): 2326-30, 1996 Sep.
Article
en Ja
| MEDLINE
| ID: mdl-8890558
ABSTRACT
The erythrocyte is a highly differentiated cell which has simple but active metabolic pathways. It lacks a nucleus, mitochondria and ribosomes, while glycolysis, hexose monophosphate pathway and glutathione synthesis maintain a high activity. Glycolysis is the only energy producing pathway crucial for red cell function and survival. The main function of red cell hexose monophosphate pathway is to generate NADPH, which is indispensable for maintaining high levels of a potent antioxidant reduced glutathione. Rapoport-Luebering pathway and pyrimidine 5'-nucleotide system are unique metabolic pathways specific for red cells. The former produces 2,3-diphosphoglycerate and the latter dephosphorylates useless pyrimidine nucleotides derived from the degenerated RNA.
Search on Google
Banco de datos:
MEDLINE
Asunto principal:
Eritrocitos
Límite:
Humans
Idioma:
Ja
Año:
1996
Tipo del documento:
Article