Correlative evidence of hypertension and altered cochlear microhomeostasis: electrophysiological changes in the spontaneously hypertensive rat.
Hear Res
; 102(1-2): 63-9, 1996 Dec 01.
Article
en En
| MEDLINE
| ID: mdl-8951451
ABSTRACT
The spontaneously hypertensive rat model has been used to show that hypertension is an important pathophysiological risk factor in age-related hearing loss. In the present study, compound action potential (CAP), electrochemical potential (ECP), and potassium concentration (CK+) measurements were taken from the cochlea of genetically predisposed, spontaneously hypertensive rats (SHR) and from normotensive Wistar-Kyoto (WKY) rats. In the SHR model, as the duration of hypertension increased with the animal's age (from 3 to 8 months), CAP thresholds increased, ECP increased in marginal cells only, and CK+ increased in both endolymph and marginal cells. Collectively, the data suggest that ionic alternations of cellular potentials are involved in hearing changes in the hypertensive state. Ultimately, such data may assist in understanding hearing loss in individuals who are diagnosed with hypertension.
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Banco de datos:
MEDLINE
Asunto principal:
Potasio
/
Envejecimiento
/
Cóclea
/
Potenciales Microfónicos de la Cóclea
/
Pérdida Auditiva Sensorineural
/
Hipertensión
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Animals
Idioma:
En
Año:
1996
Tipo del documento:
Article