Amarogentin, a naturally occurring secoiridoid glycoside and a newly recognized inhibitor of topoisomerase I from Leishmania donovani.

Ray, S; Majumder, H K; Chakravarty, A K; Mukhopadhyay, S; Gil, R R; Cordell, G A

Ray, S; Majumder, H K; Chakravarty, A K; Mukhopadhyay, S; Gil, R R; Cordell, G A.

Ray S; Indian Institute of Chemical Biology, Calcutta, India.

J Nat Prod ; 59(1): 27-9, 1996 Jan.

Article en En | MEDLINE | ID: mdl-8984149

ABSTRACT

ABSTRACT

A MeOH extract of Swertia chirata found to inhibit the catalytic activity of topoisomerase I of Leishmania donovani was subjected to fractionation to yield three secoiridoid glycosides amarogentin (1), amaroswerin (2), and sweroside (3). Amarogentin is a potent inhibitor of type I DNA topoisomerase from Leishmania and exerts its effect by interaction with the enzyme, preventing binary complex formation.

Asunto(s)

Inhibidores Enzimáticos/aislamiento & purificación; Inhibidores Enzimáticos/farmacología; Glucósidos/aislamiento & purificación; Iridoides; Leishmania donovani/enzimología; Plantas Medicinales/química; Piranos/aislamiento & purificación; Inhibidores de Topoisomerasa I; Animales; ADN Protozoario/química; ADN Protozoario/efectos de los fármacos; Glucósidos/química; Glucósidos/farmacología; India; Espectroscopía de Resonancia Magnética; Piranos/química; Piranos/farmacología

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Banco de datos: MEDLINE Asunto principal: Plantas Medicinales / Piranos / Leishmania donovani / Iridoides / Inhibidores Enzimáticos / Inhibidores de Topoisomerasa I / Glucósidos Límite: Animals País como asunto: Asia Idioma: En Año: 1996 Tipo del documento: Article

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