Relationship between antigenicity and immunogenicity of chimeric hepatitis B virus core particles carrying HIV type 1 epitopes.
AIDS Res Hum Retroviruses
; 13(1): 41-51, 1997 Jan 01.
Article
en En
| MEDLINE
| ID: mdl-8989426
ABSTRACT
We have developed a comparative study of antigenic and immunogenic properties of selected immunodominant HIV-1 epitopes from p24 and gp120 proteins added to C-terminally truncated hepatitis B virus (HBV) core protein and exposed on the surface of chimeric core particles. Inserted p24 (121-210) and gp120/MN (306-328) epitopes induced the appropriate humoral and cellular immune responses against HIV-1. Superficially exposed region 160-192 of p24 also showed maximal B cell immunogenicity whereas buried region 148-162 induced maximal T cell response. Both recombinant proteins were also able to be recognized in vitro by T lymphocytes of HIV-1 asymptomatic carriers.
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Banco de datos:
MEDLINE
Asunto principal:
Virus de la Hepatitis B
/
Epítopos Inmunodominantes
/
VIH-1
/
Vacunas contra el SIDA
Límite:
Adult
/
Animals
/
Female
/
Humans
/
Male
Idioma:
En
Año:
1997
Tipo del documento:
Article