Alkaloid 223A: the first trisubstituted indolizidine from dendrobatid frogs.
J Nat Prod
; 60(1): 2-5, 1997 Jan.
Article
en En
| MEDLINE
| ID: mdl-9014346
ABSTRACT
The structure of alkaloid 223A (1), the first member of a new class of amphibian alkaloids, purified by HPLC from a skin extract of a Panamanian population of the frog Dendrobates pumilio Schmidt (Dendrobatidae) has been established as (5R,6S,8R,9S)- or (5S,6R,8S,9R)-6,8-diethyl-5-propylindolizidine, based on GC-MS, GC-FTIR, and 1H-NMR spectral studies. Three higher homologs of 223A, namely alkaloids 237L (2), 251M (3), and 267J (4), have been detected in other extracts, and tentative structures are proposed.
Search on Google
Banco de datos:
MEDLINE
Asunto principal:
Anuros
/
Indolizinas
Límite:
Animals
País como asunto:
America central
/
Panama
Idioma:
En
Año:
1997
Tipo del documento:
Article