Heterogeneity of expression of the calcium-binding protein calretinin in human colonic cancer cell lines.
Anticancer Res
; 16(6B): 3491-8, 1996.
Article
en En
| MEDLINE
| ID: mdl-9042211
ABSTRACT
We searched for the presence of calretinin (CR) in 12 colonic cancer cell lines using immunohistochemistry, Western blot analysis and the reverse transcriptase-polymerase chain reaction (RT-PCR). We were able to demonstrate that calretinin is expressed in the cell lines HT-29, WiDr, LoVo, LS180, CO112, CO115. SW480, SW620, COLO205 and SK-CO-1, while no detectable amounts were found in the cell lines SW1116 and Caco-2. In general, rapidly proliferating cell lines expressed calretinin, whereas the protein was absent from cell lines with a low multiplication rate. A possible role for calretinin in maintaining the proliferative cycle of tumor cells is discussed.
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Banco de datos:
MEDLINE
Asunto principal:
Proteína G de Unión al Calcio S100
/
Adenocarcinoma
/
Neoplasias del Colon
/
Proteínas de Neoplasias
Límite:
Humans
Idioma:
En
Año:
1996
Tipo del documento:
Article