[Interaction of immune and normal macrophages with the influenza virus]. / Vzaimodeistvie immunnykh i normal'nykh makrofagov s virusom grippa.

ABSTRACT

The interaction of macrophage cultures from immune and non-immune animals with influenza A/PR8/34 virus was studied. Significant differences were demonstrated between immune and normal macrophages. Influenza virus could be found in immune macrophages for a considerably shorter period than in normal macrophages. In immune macrophage cultures as compared with normal macrophages the synthesis of V- and S-antigens occurred only in a small number of cells. The study of the hemadsorbing capacity of macrophages showed the number of cells adsorbing erythrocytes to increase in normal macrophage cultures in contrast to those of immune macrophages. When macrophage cultures were inoculated with influenza virus, it exerted a cytopathic effect on normal macrophages at a lower multiplicity of infection whereas much greater infectious doses were required to produce the CPE in immune macrophages. The experimental results suggest that in infection or immunization certain changes occur in macrophages which may play a role in elimination of influenza virus from the body and in immune response.