[Bacterial synthesis of immunogenic epitopes of foot-and-mouth disease virus fused either to human necrosis factor or to hepatitis B core antigen]. / Bakterial'nyi sintez immunogennykh épitopov virusa iashchura v sostave gibridov s faktorom nekroza opukholei i kor-antigenom virusa gepatita B.
Bioorg Khim
; 23(2): 118-26, 1997 Feb.
Article
en Ru
| MEDLINE
| ID: mdl-9157845
ABSTRACT
Using recombinant DNA technology, construction and bacterial expression of genes was carried out which code for hybrid proteins, human tumor necrosis factor and hepatitis B core protein fused to immunogenic epitopes of foot-and-mouth disease virus, strains A22 and O1-194. Hybrids of tumor necrosis factor with foot-and-mouth disease antigenic determinants protected laboratory animals against the experimental challenge with a homologous strain of foot-and-mouth disease virus. Hybrid protein that contained immunogenic regions of two strains, A22 and O1-194, protected animals against infection with both A and O serotypes. Hybrid proteins based on hepatitis B virus core antigen retained the ability to assemble into core-like particles.
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Banco de datos:
MEDLINE
Asunto principal:
Factor de Necrosis Tumoral alfa
/
Aphthovirus
/
Antígenos del Núcleo de la Hepatitis B
/
Epítopos
Límite:
Animals
/
Humans
Idioma:
Ru
Año:
1997
Tipo del documento:
Article