Sex chromosome markers: characterization using fluorescence in situ hybridization and review of the literature.
Am J Med Genet
; 71(1): 1-7, 1997 Jul 11.
Article
en En
| MEDLINE
| ID: mdl-9215760
ABSTRACT
Fluorescence in situ hybridization (FISH) using biotin labeled X- and Y-chromosome DNA probes was utilized in the analysis of 23 sex chromosome-derived markers. Specimens were obtained through prenatal diagnosis, because of a presumptive diagnosis of Ullrich-Turner syndrome, mental retardation, and minor anomalies or ambiguous genitalia; three were spontaneous abortuses. Twelve markers were derived from the X chromosome and eleven from the Y chromosome; this demonstrates successfully the value and necessity of FISH utilizing DNA probes in the identification of sex chromosome markers. Both fresh and older slides, some of which had been previously G-banded, were used in these determinations. We have also reviewed the literature on sex chromosome markers identified using FISH.
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Banco de datos:
MEDLINE
Asunto principal:
Cromosomas Sexuales
/
Marcadores Genéticos
Límite:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
/
Newborn
Idioma:
En
Año:
1997
Tipo del documento:
Article