Primary sinusoidal lymphoma of the liver revealed by autoimmune hemolytic anemia.
Gastroenterol Clin Biol
; 21(6-7): 514-8, 1997.
Article
en En
| MEDLINE
| ID: mdl-9295981
ABSTRACT
Primary liver lymphomas usually present with the clinical picture of a liver tumor, and are characterized by a predominantly portal invasion by lymphoid cells of the B-cell phenotype. We report a case of primary sinusoidal lymphoma of the liver, in a 36 year-old male patient, revealed by homogeneous hepatosplenomegaly and infiltration of liver sinusoids by morphologically normal lymphocytes, without destruction of the parenchyma. Immunohistochemistry in paraffin-embedded tissue sections was positive for the pan T-cell marker MTI, weakly positive for UCHLI, and negative for CD3, and B-cell markers were negative; these findings were consistent with the diagnosis of T-cell lymphoma. The clinical, histological and immunological presentation of this lymphoma was similar to that of hepatosplenic gamma delta T-cell lymphoma. Autoimmune hemolytic anaemia preceded the lymphoma. Despite chemotherapy, the patient died 24 months after the initial presentation in the leukemic phase. A better understanding of this exceptional but characteristic entity is required for an accurate and early diagnosis.
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Banco de datos:
MEDLINE
Asunto principal:
Linfoma de Células T
/
Anemia Hemolítica Autoinmune
/
Neoplasias Hepáticas
Tipo de estudio:
Screening_studies
Límite:
Adult
/
Humans
/
Male
Idioma:
En
Año:
1997
Tipo del documento:
Article