Thymidylate synthase is a predictor for response and resistance in hepatic artery infusion chemotherapy.
Cancer Lett
; 118(1): 29-35, 1997 Sep 16.
Article
en En
| MEDLINE
| ID: mdl-9310257
ABSTRACT
The value of intratumoral thymidylate synthase (TS) quantitation as a predictive parameter for hepatic artery infusion (HAI) chemotherapy in patients with colorectal liver metastases was investigated. Relative TS mRNA levels were determined in 29 tumor samples using a quantitative RT-PCR amplification method. The median level of expression was 3.0 x 10(-3) (no units) and varied considerably among the tumors over a range of 135-fold. Patients with low TS levels were 4.1-fold more likely to respond (P < 0.03) compared to patients with high TS levels. Our results indicate that TS quantitation is a valuable predictive marker for tumor response to HAI therapy.
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Banco de datos:
MEDLINE
Asunto principal:
Timidilato Sintasa
/
Neoplasias Colorrectales
/
Protocolos de Quimioterapia Combinada Antineoplásica
/
Floxuridina
/
Fluorouracilo
/
Neoplasias Hepáticas
/
Antimetabolitos Antineoplásicos
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Año:
1997
Tipo del documento:
Article