Effect of mercuric ions on human erythrocytes. Relationships between hypotonic swelling and cell aggregation.
Biochim Biophys Acta
; 1328(2): 273-80, 1997 Sep 04.
Article
en En
| MEDLINE
| ID: mdl-9315623
ABSTRACT
This study was undertaken to verify the hypothesis that the haemolytic effect of mercuric ions on human erythrocytes is strongly decreased under swelling conditions (relative to isotonic suspensions). In fact, interaction of Hg2+ with swollen erythrocytes yields a rapid and cooperative cell aggregation, a phenomenon that appears to prevent penetration of mercuric ions into the cells and, accordingly, to avoid any haemolytic effect induced by the Hg2+ entrance. Since in vivo erythrocytes undergo big shape changes (swelling being a kind of shape modification) related to mechanical or (in some animals) osmotic stresses, the reported observations turn out to be also of some relevance for the understanding of certain toxicological effects of mercuric ions.
Search on Google
Banco de datos:
MEDLINE
Asunto principal:
Agregación Eritrocitaria
/
Eritrocitos
/
Hemólisis
/
Mercurio
Límite:
Humans
Idioma:
En
Año:
1997
Tipo del documento:
Article