Simian immunodeficiency virus burden in tissues and cellular compartments during clinical latency and AIDS.
J Infect Dis
; 176(5): 1198-208, 1997 Nov.
Article
en En
| MEDLINE
| ID: mdl-9359719
ABSTRACT
In the course of human immunodeficiency virus infection or of the related simian immunodeficiency virus (SIV), progression to AIDS is associated with high virus burdens in blood. How virus burden in the bloodstream is related to virus burden in tissue reservoirs was addressed in an animal model of rhesus macaques infected with SIV. In situ hybridization and quantitative image analysis were used to quantitate virus burden. Animals who developed AIDS had high levels of virus production and storage in lymphoid tissue reservoirs and evidence of productive infection of macrophages in the nervous system. With the quantitative approach described, it should be possible to design and assess the impact of treatment and shed light on the outstanding issues in pathogenesis.
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Banco de datos:
MEDLINE
Asunto principal:
Síndrome de Inmunodeficiencia Adquirida del Simio
/
Virus de la Inmunodeficiencia de los Simios
/
Latencia del Virus
Límite:
Animals
Idioma:
En
Año:
1997
Tipo del documento:
Article