Role of inositol 1,4,5-trisphosphate receptor in ventral signaling in Xenopus embryos.
Science
; 278(5345): 1940-3, 1997 Dec 12.
Article
en En
| MEDLINE
| ID: mdl-9395395
ABSTRACT
The inositol 1,4,5-trisphosphate (IP3) receptor is a calcium ion channel involved in the release of free Ca2+ from intracellular stores. For analysis of the role of IP3-induced Ca2+ release (IICR) on patterning of the embryonic body, monoclonal antibodies that inhibit IICR were produced. Injection of these blocking antibodies into the ventral part of early Xenopus embryos induced modest dorsal differentiation. A close correlation between IICR blocking potencies and ectopic dorsal axis induction frequency suggests that an active IP3-Ca2+ signal may participate in the modulation of ventral differentiation.
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Banco de datos:
MEDLINE
Asunto principal:
Canales de Calcio
/
Transducción de Señal
/
Inositol 1,4,5-Trifosfato
/
Calcio
/
Receptores Citoplasmáticos y Nucleares
/
Tipificación del Cuerpo
/
Embrión no Mamífero
Límite:
Animals
Idioma:
En
Año:
1997
Tipo del documento:
Article