CD36 forms covalently associated dimers and multimers in platelets and transfected COS-7 cells.
Biochem Biophys Res Commun
; 240(3): 812-8, 1997 Nov 26.
Article
en En
| MEDLINE
| ID: mdl-9398651
ABSTRACT
CD36 is a transmembrane glycoprotein expressed on the surface of a number of cell types. The analysis of CD36 from platelets using immunoblotting, gel filtration, and native PAGE indicated the presence of high molecular complexes exceeding the Mr of monomeric CD36. Experiments using transfected COS-7 cells revealed these complexes were homodimers and -multimers of CD36. The multimers could be dissociated by treatment with a reducing agent, indicating they were formed by intermolecular cysteine-bridging. Mutagenesis of the cDNA for CD36 implicated the cysteines in the extracellular domain of the molecule. The potential physiological roles of CD36 multimerisation are discussed.
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Banco de datos:
MEDLINE
Asunto principal:
Conformación Proteica
/
Plaquetas
/
Antígenos CD36
Tipo de estudio:
Risk_factors_studies
Límite:
Animals
Idioma:
En
Año:
1997
Tipo del documento:
Article