Cytogenetic findings in malignant mixed mesodermal tumors of the uterus.
Cancer Genet Cytogenet
; 99(2): 121-5, 1997 Dec.
Article
en En
| MEDLINE
| ID: mdl-9398866
ABSTRACT
Cytogenetic analyses of four malignant mixed mesodermal tumors (MMMT) of the uterus are reported, of which one was of the homologous type and three of the heterologous. Karyotypic analyses were obtained in two cases from original tumors and in two cases from tumors xenotransplanted into nude mice. The karyotype of the homologous MMMT was normal in three different passages of a nude mice xenograft line established from the primary tumor. The heterologous tumors showed normal karyotype in one case and hyperdiploid and near triploid range with extensive numerical and structural rearrangements in two cases. Deletion of chromosome 1 at p32, and deletion of chromosome 11 at q13 were common markers in anomalous cases. The chromosomes most often involved in structural rearrangements were chromosomes 1, 9, 11, 12, 17, and 19. Double minutes, homogeneously staining regions, and telomeric association were also seen.
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Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Uterinas
/
Tumor Mesodérmico Mixto
Tipo de estudio:
Diagnostic_studies
Límite:
Aged
/
Animals
/
Female
/
Humans
/
Middle aged
Idioma:
En
Año:
1997
Tipo del documento:
Article