Effects of in-vivo generation of oxygen free radicals on immune responsiveness in rabbits.
Immunol Lett
; 59(3): 127-31, 1997 Dec.
Article
en En
| MEDLINE
| ID: mdl-9419018
ABSTRACT
Oxygen free radicals (OFRs) generated during biological processes are reportedly involved in the pathogenesis of several disease states and various reports have indicated that oxidative stress may alter immune competence. Hence, effects of in-vivo generation of OFRs by using xanthine/xanthine oxidase (X/XO) system on immune responsiveness were evaluated in rabbits. Intravenous injections of xanthine (0.14 mg/kg) along with xanthine oxidase (2 U/Kg) following primary and secondary immunizations of animals with sheep red blood cells (SRBC) significantly attenuated the primary and secondary antibody responses respectively. In tests for cell-mediated immunity, tuberculin sensitivity and leucocyte migration inhibition were also decreased significantly in sensitized animals following X/XO treatment. The observed changes in both humoral and cell-mediated immune responses following such in-vivo generation of OFRs indicate a possible nexus between OFR generation and immune suppression.
Search on Google
Banco de datos:
MEDLINE
Asunto principal:
Xantina Oxidasa
/
Especies Reactivas de Oxígeno
/
Xantina
Límite:
Animals
Idioma:
En
Año:
1997
Tipo del documento:
Article