Transmembrane redox signaling activates NF-kappaB in macrophages.
Free Radic Biol Med
; 24(1): 202-7, 1998 Jan 01.
Article
en En
| MEDLINE
| ID: mdl-9436632
ABSTRACT
In macrophages, NF-kappaB can be activated by H2O2 generated by the respiratory burst or added exogenously. The mechanism of H2O2 signaling may involve changes in the cellular redox state or a redox reaction at the plasma membrane; however, the site of H2O2 action cannot be readily ascertained because of its membrane permeability. Ferricyanide, a nonpermeable redox active anion, activated NF-kappaB in the macrophage cell line, J774A.1. In contrast with exogenous H2O2, activation by ferricyanide did not correlate with net oxidation of NAD(P)H or glutathione, suggesting that a transplasma membrane redox reaction itself was the first signaling process in NF-kappaB activation.
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Banco de datos:
MEDLINE
Asunto principal:
Transducción de Señal
/
FN-kappa B
/
Estallido Respiratorio
/
Peróxido de Hidrógeno
/
Macrófagos
Límite:
Animals
Idioma:
En
Año:
1998
Tipo del documento:
Article