Modulation of gamma glutamyl transpeptidase activity in lymphoid system by organochlorine pesticides in rats.
Indian J Exp Biol
; 35(10): 1132-4, 1997 Oct.
Article
en En
| MEDLINE
| ID: mdl-9475050
ABSTRACT
Effects of 1,1,1,-trichloro-2,2-bis (p-chlorophenyl) ethane (DDT) and lindane were studied on gamma glutamyl transpeptidase (GGT) activity in different tissues of the lymphoid system in rats. DDT (100 or 200 ppm) and lindane (30 or 80 ppm) exposure for 8 weeks suppressed the GGT activity in a dose dependent manner in thymus and macrophage. In spleen, significant decrease in the enzyme activity was observed at higher exposure (200 ppm DDT or 80 ppm lindane) levels. Lindane suppressed GGT activity at both 30 or 80 ppm dose levels, while DDT reduced the GGT activity at 200 ppm but not at 100 ppm exposure in lymphocyte. The study indicates the possibility of using GGT as an effective and consistent biochemical marker for immunotoxicity of xenobiotics and other environmental stressors.
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Banco de datos:
MEDLINE
Asunto principal:
Linfocitos
/
Gamma-Glutamiltransferasa
/
Hidrocarburos Clorados
/
Insecticidas
/
Tejido Linfoide
/
Macrófagos
Límite:
Animals
Idioma:
En
Año:
1997
Tipo del documento:
Article