Insolubilization test of sodium chondroitin sulphate with a view to its use as colonic carrier of drugs.
J Biomater Appl
; 12(3): 201-21, 1998 Jan.
Article
en En
| MEDLINE
| ID: mdl-9493068
ABSTRACT
Several studies have been devoted to cross-linked sodium chondroitin sulphate (SCS), in the context of numerous strategies attempting to target the colon for the absorption or the therapeutic action of a drug. SCS, a glycosaminoglycan presenting a specific degradation in the colon, is in fact soluble in water and its use as drug carrier at such a distance from the digestive tube necessitates its hydrophobisation. One method described in the literature consists in manufacturing a three-dimensional network by cross-linking with bifunctional compounds. However, all the structural characterisations carried out on the products resulting from the catalysed treatments of SCS with diaminoalkanes demonstrate that there are no cross-linking bridges between the polymer chains. Moreover, treated SCS-based tablets containing theophylline as model drug lead in vitro to dissolution profiles which are identical to those obtained with the non-treated SCS. We were therefore unable to find the announced results using the method described.
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Banco de datos:
MEDLINE
Asunto principal:
Portadores de Fármacos
/
Sulfatos de Condroitina
/
Colon
Idioma:
En
Año:
1998
Tipo del documento:
Article