[Predictors of hospital mortality in the thrombolytic era for acute myocardial infarction in Salvador, State of Bahia, Brazil]. / Preditores de mortalidade hospitalar na era trombolítica para o infarto agudo do miocárdio em Salvador (BA).

ABSTRACT

PURPOSE: To determine the cumulative incidence and risk factors of in-hospital death due to acute myocardial infarction (AMI) in the thrombolytic era and to assess the degree of incorporation of new therapeutical interventions to the treatment of AMI in Salvador, Brazil. METHODS: A retrospective study based on medical records of 388 patients hospitalized with an AMI in different hospitals between January 1993 and December 1994. The relative risk (RR) was used as a measure of association for the unadjusted analysis. To control for possible confoundears and to assess interactions, odds ratios (OR) were used to estimate the RR, by logistic regression models. RESULTS: During the hospitalization period 50 (12.9%) patients died. The main predictors of hospital mortality in the unadjusted comparisons were older age (age > 60 years) (RR = 2.76; p < 0.01), female gender (RR = 2.08; p = 0.01), Killip class > 1 (RR = 5.73; p < 0.01), anterior wall AMI (RR = 1.92; p = 0.02), previous stroke (RR = 4.13; p < 0.01) and systemic disease (RR = 2.76; p < 0.01). In the multivariate analysis, older age (OR = 2.42; p = 0.02), Killip class > 1 (OR = 7.14; p < 0.01), anterior wall AMI (RR = 2.37; p = 0.02) and previous stroke (RR = 2.34; p = 0.04) were the main independent predictors of hospital death. Thrombolytic therapy was used in 143 patients (36.8%), aspirin in 322 (83%), beta blockers in 204 (52.6%) and heparin in 248 (63.9%). Cardiogenic shock was responsible for more than half of the death cases. CONCLUSION: Based on the data presented, older age, Killip class and anterior wall infarction are still important predictors of death due to AMI in the thrombolytic era, confirming other studies.