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Altered guanosine and guanine concentrations in rabbit striatum following increased dopamine turnover.
Loeffler, D A; LeWitt, P A; Juneau, P L; Camp, D M; DeMaggio, A J; Milbury, P; Matson, W R; Rathbone, M P.
  • Loeffler DA; Clinical Neuroscience Program, Sinai Hospital, Detroit, MI 48235, USA.
Brain Res Bull ; 45(3): 297-9, 1998.
Article en En | MEDLINE | ID: mdl-9510422
ABSTRACT
The significance of guanine nucleotides and nucleosides in neurodegenerative disorders is suggested by recent reports that these molecules enhance neurite branching and astrocyte proliferation. The objective of this study was to investigate the influence of increased dopamine metabolism, produced by 5-day treatment of rabbits with reserpine (2 mg/kg) or levodopa (LD) (50 mg/kg), on striatal concentrations of guanosine, guanine, and their metabolites. Reserpine treatment decreased striatal guanosine by 41% and increased guanine by 50%, while LD decreased guanosine by 48% (all p < 0.01 vs. vehicle-treated controls). LD also increased guanine by 22% (not statistically significant). Xanthine and uric acid concentrations were unchanged. Because of the neurotrophic properties of guanosine and guanine, changes in striatal concentrations of these purines secondary to increased dopamine (DA) turnover may have relevance for survival of remaining dopaminergic neurons in Parkinson's disease (PD).
Asunto(s)
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Banco de datos: MEDLINE Asunto principal: Reserpina / Dopaminérgicos / Dopamina / Cuerpo Estriado / Guanina / Guanosina Límite: Animals Idioma: En Año: 1998 Tipo del documento: Article
Search on Google
Banco de datos: MEDLINE Asunto principal: Reserpina / Dopaminérgicos / Dopamina / Cuerpo Estriado / Guanina / Guanosina Límite: Animals Idioma: En Año: 1998 Tipo del documento: Article