Treatment of severe clozapine-induced neutropenia with granulocyte colony-stimulating factor (G-CSF). Remission despite continuous treatment with clozapine.
Br J Psychiatry
; 172: 82-4, 1998 Jan.
Article
en En
| MEDLINE
| ID: mdl-9534838
ABSTRACT
BACKGROUND:
A 17-year-old boy suffering from a severe schizophrenic disorder of the paranoid type and mental retardation did not respond to treatment with typical antipsychotics, whereas under clozapine treatment he showed a favourable response. Discontinuation of clozapine led to an acute psychotic relapse. During clozapine treatment the patient developed severe neutropenia. METHOD ANDRESULTS:
Due to the history of unsatisfactory response to traditional antipsychotics, clozapine treatment was continued despite white blood cell (WBC) decline. Concomitant treatment with G-CSF was followed by a rapid normalisation of WBC.CONCLUSIONS:
This case report is not intended to challenge the clinical practice of discontinuing clozapine upon the development of neutropenia/agranulocytosis, but rather to stimulate further research in the pathophysiology and clinical consequences of a clozapine rechallenge after a WBC decline, especially in patients with a rather complex symptomatology where no sufficient therapeutic results can be achieved with any other pharmacological intervention than clozapine.
Search on Google
Banco de datos:
MEDLINE
Asunto principal:
Antipsicóticos
/
Factor Estimulante de Colonias de Granulocitos
/
Clozapina
/
Neutropenia
Límite:
Adolescent
/
Humans
/
Male
Idioma:
En
Año:
1998
Tipo del documento:
Article