The pentoxifylline experience: exercise testing reconsidered.
Vasc Med
; 1(2): 145-54, 1996.
Article
en En
| MEDLINE
| ID: mdl-9546930
ABSTRACT
This paper critically reviews the methodology used in clinical trials in chronic occlusive arterial disease (COAD) stage II (intermittent claudication) patients. The reasons for choosing internationally accepted standard treadmill settings as well as its limitations are discussed. Emphasis is put on the discussion of valid trial endpoints such as hemodynamic surrogates and clinically oriented parameters. Reasons for a spontaneous and treatment-unrelated improvement in claudication distance are elucidated, and variables which may be used for the definition of patient subsamples showing a high frequency of a pronounced treatment response (treatment responder populations) are presented. The magnitude of claudication distance improvement that might be considered clinically relevant is discussed in the light of the European Union guidelines for clinical trials in COAD patients. Results achieved with pentoxifylline are presented in context with all variables mentioned above.
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Banco de datos:
MEDLINE
Asunto principal:
Pentoxifilina
/
Vasodilatadores
/
Prueba de Esfuerzo
/
Claudicación Intermitente
Tipo de estudio:
Clinical_trials
/
Guideline
/
Qualitative_research
Límite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
País como asunto:
America do norte
/
Europa
Idioma:
En
Año:
1996
Tipo del documento:
Article