Lithium regulation of protein phosphorylation in rat cerebral cortex slices in vitro.
Biochem Mol Biol Int
; 44(3): 497-505, 1998 Mar.
Article
en En
| MEDLINE
| ID: mdl-9556210
ABSTRACT
The aim of the present study was to evaluate the direct effect of Li+ and Na+-Li+ exchange on protein phosphorylation in rat cerebral cortex slices incubated in Krebs Ringer medium. When Na+ concentration was varied in the incubation medium, either by replacement with Li+ or sucrose, a variable effect on [32P] phosphate incorporation into proteins was observed. Protein phosphorylation in cerebral cortex slices was very low in the absence of Na+, and some dependence of phosphorylating system of neural tissue on extra cellular concentration of Na+ was evident. Lithium was not able to replace sodium as far as protein phosphorylation in cortical slices is concerned. Ouabain was more effective in a Li+ containing medium in inhibiting protein phosphorylation, presumably due to improper functioning of the sodium pump.
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Banco de datos:
MEDLINE
Asunto principal:
Proteínas
/
Corteza Cerebral
/
Litio
Límite:
Animals
Idioma:
En
Año:
1998
Tipo del documento:
Article