Severe mycobacterial and Salmonella infections in interleukin-12 receptor-deficient patients.
Science
; 280(5368): 1435-8, 1998 May 29.
Article
en En
| MEDLINE
| ID: mdl-9603733
ABSTRACT
Interleukin-12 (IL-12) is a cytokine that promotes cell-mediated immunity to intracellular pathogens by inducing type 1 helper T cell (TH1) responses and interferon-gamma (IFN-gamma) production. IL-12 binds to high-affinity beta1/beta2 heterodimeric IL-12 receptor (IL-12R) complexes on T cell and natural killer cells. Three unrelated individuals with severe, idiopathic mycobacterial and Salmonella infections were found to lack IL-12Rbeta1 chain expression. Their cells were deficient in IL-12R signaling and IFN-gamma production, and their remaining T cell responses were independent of endogenous IL-12. IL-12Rbeta1 sequence analysis revealed genetic mutations that resulted in premature stop codons in the extracellular domain. The lack of IL-12Rbeta1 expression results in a human immunodeficiency and shows the essential role of IL-12 in resistance to infections due to intracellular bacteria.
Search on Google
Banco de datos:
MEDLINE
Asunto principal:
Infecciones por Salmonella
/
Tuberculosis
/
Infección por Mycobacterium avium-intracellulare
/
Receptores de Interleucina
/
Interleucina-12
/
Mycobacterium bovis
Límite:
Adult
/
Child, preschool
/
Female
/
Humans
Idioma:
En
Año:
1998
Tipo del documento:
Article