Evolution to malignancy in a recurrent meningioma: morphological and cytogenetic findings.
Clin Neuropathol
; 17(4): 210-5, 1998.
Article
en En
| MEDLINE
| ID: mdl-9707336
ABSTRACT
The original tumor and 4 relapses of a recurrent meningioma were studied. We analyzed and compared these recurrences by histopathology, PCNA labelling index (PCNA-LI), nuclear count, and cytogenetical findings. The most important changes in the evolution to aggressivity were recurrences at progressively shorter intervals, increases in the PCNA-LI, and micronecrosis; histological changes such as sheeting and increase of the extracellular matrix and a gradual transformation to a clonally complex karyotype.
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Banco de datos:
MEDLINE
Asunto principal:
Transformación Celular Neoplásica
/
Neoplasias Meníngeas
/
Meningioma
/
Recurrencia Local de Neoplasia
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
/
Male
/
Middle aged
Idioma:
En
Año:
1998
Tipo del documento:
Article