Strategies to prevent thrombosis in xenotransplants.
Transplant Proc
; 30(5): 2458-60, 1998 Aug.
Article
en En
| MEDLINE
| ID: mdl-9723536
ABSTRACT
Coagulation remains a major barrier to successful xenotransplantation. Identification of the role of complement activation in HAR and prevention of complement activation by high expression of DAF and CD59 has largely overcome HAR. Understanding the molecular basis of DXR and identification of novel strategies to prevent activation of endothelial cells using monoclonal antibodies, soluble inhibitors of coagulation, vaccination, antisense constructs, and recombinant DNA technology offers the promise of overcoming the thrombosis associated with xenotransplantation.
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Banco de datos:
MEDLINE
Asunto principal:
Complicaciones Posoperatorias
/
Trombosis
/
Trasplante Heterólogo
/
Coagulación Sanguínea
/
Rechazo de Injerto
Límite:
Animals
/
Humans
Idioma:
En
Año:
1998
Tipo del documento:
Article