Arterial thromboembolic events in patients with the factor V Leiden mutation.
Am J Surg
; 176(2): 122-5, 1998 Aug.
Article
en En
| MEDLINE
| ID: mdl-9737615
ABSTRACT
BACKGROUND:
The factor V Leiden mutation affects 6% of the United States population and is known to be associated with venous thrombosis. We identify, herein, 30 individuals with the Leiden mutation and known arterial thromboembolic events.METHODS:
The factor V mutation was assessed using polymerase chain reaction.RESULTS:
In the 16 patients sustaining a cerebrovascular accident, the mean age was 44.1 and 11 (69%) were younger than 50. Similarly, the 13 patients presenting with an acute myocardial infarction were relatively young with a mean age of 45.5, and 9 (65%) patients presented at less than 50 years of age. Radiographic information was available for 19 patients in this study. No significant arterial atherosclerotic disease was demonstrated in 18 (95%) of these patients.CONCLUSIONS:
This study demonstrates an association between the factor V Leiden mutation and the development of unexplained arterial thromboembolic events, especially in younger patients without existing atherosclerotic disease.
Search on Google
Banco de datos:
MEDLINE
Asunto principal:
Tromboembolia
/
Factor V
/
Mutación Puntual
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
Límite:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Año:
1998
Tipo del documento:
Article