Synthesis of some new benzimidazolecarboxamides and evaluation of their antimicrobial activity.
Farmaco
; 53(6): 415-20, 1998 Jun 30.
Article
en En
| MEDLINE
| ID: mdl-9764474
ABSTRACT
A series of 1,2-disubstituted benzimidazole-5(6)-carboxamides was prepared and evaluated in vitro for antimicrobial activity against Staphyloccus aureus, Escherichia coli and Candida albicans. The precursor benzimidazolecarboxylic acids 4a-c and 9a-c were prepared via oxidative condensation of diaminobenzoic acids with aldehydes and via several steps over the 2(1H)-benzimidazolones, respectively. All acids were converted to their acyl chlorides with SOCl2, then amidified with several N,N'-dialkylaminoethyl derivatives. Compounds 8a-c, 20 and 22 exhibited the best activity.
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Banco de datos:
MEDLINE
Asunto principal:
Staphylococcus aureus
/
Bencimidazoles
/
Candida albicans
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Escherichia coli
/
Antiinfecciosos
Idioma:
En
Año:
1998
Tipo del documento:
Article