Mouse Brachyury the Second (T2) is a gene next to classical T and a candidate gene for tct.
Genetics
; 150(3): 1125-31, 1998 Nov.
Article
en En
| MEDLINE
| ID: mdl-9799264
ABSTRACT
The mouse Brachyury the Second (T2) gene is 15 kb away from classical Brachyury (T). A mutation in T2 disrupts notochord development, pointing to the existence of a second T/t complex gene involved in axis development. T2 encodes a novel protein that is disrupted by an insertion in T2(Bob) mice. Sequence analysis of T2 from several t haplotypes shows that they all share the same changed stop codon, and, thus, T2 is a candidate gene for the t complex tail interaction factor. T1, T2, and the unlinked t-int are distinct and unrelated loci, and mutations in these genes do not complement one another genetically. Either their products interact in the same pathway during the genesis of the embryonic axis, or the T/t region itself is truly complex.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Factores de Transcripción
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Mapeo Cromosómico
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Genoma
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Proteínas de Dominio T Box
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Proteínas de Unión al ADN
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Proteínas Fetales
Límite:
Animals
Idioma:
En
Año:
1998
Tipo del documento:
Article