Pregnancy and progeny in rats treated with the pyrrolizidine alkaloid fulvine
Exp Pathol Jena
; 9(1-2): 59-63, 1974.
Article
en En
| MedCarib
| ID: med-7814
Biblioteca responsable:
JM3.1
Ubicación: JM3.1; Reprint Collection
ABSTRACT
The pyrrolizidine alkaloids are naturally-occurring plants toxins which are considered significant in the etiology of certain liver diseases, particularly in some tropical and sub-tropical regions. Fulvine, a hepatotoxic alkloid present in the medicinal herb Crotolaria fulva, was observed to be fetotoxic and highly teratogenic in rats. The occurrence of fetal resorptions showed a dose-effect relationship. The highest incidence of developmental defects was induced by fulvine at a dose-level of 80 mg/kg which in other studies produced significant chromosomal damage. Microscopic examination of fetal liver, following maternal exposure of fulvine, did not reveal hepatic lesions.(Summary)
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Banco de datos:
MedCarib
Asunto principal:
Anomalías Inducidas por Medicamentos
Límite:
Animals
Idioma:
En
Año:
1974
Tipo del documento:
Article