Discussion on the medication law of TCM compound patents in treating polycystic ovary syndrome / 国际中医中药杂志

ABSTRACT

Objective:To analyze the medication and compatibility law of TCM compounds with national patents for the treatment of polycystic ovary syndrome (PCOS); To provide reference for the new TCM prescriptions for the treatment of PCOS.Methods:TCM compound patents for PCOS were retrieved from the China National Intellectual Property Administration's Chinese Patent Announcement Website from the establishment of the website to April 20, 2023. SPSS 25.0, IBM SPSS Modeler 18.0, and Cytoscape 3.8.0 were used to carry out frequency statistics, association rule analysis on the data, and a TCM core complex network and systematic clustering analysis were built.Results:126 compound patents were included, involving 392 kinds of Chinese materia medica, with a total frequency of 1 709 times. The medicinal property was mainly warm, the taste was mainly sweet, and the meridian was mainly liver meridian. High frequency drugs included Angelica Sinensis (46 times), Cuscutae Semen (44 times), Cyperi Rhizoma (42 times), Rehmanniae Radix Praeparata (41 times), Salviae Miltiorrhizae Radix et Rhizoma (37 times), etc. Commonly used medicinal pairs included Poria-Atractylodis Macrocephalae Rhizoma (support 16.67%, confidence 76.19%), Angelica Sinensis-Paeoniae Radix Alba (support 15.87%, confidence 80.00%), etc. The triple drug combinations were Cyperi Rhizoma-Pinelliae Rhizoma-Poria (support 12.70%, confidence 81.25%). The core prescriptions included "Poria, Pinelliae Rhizoma, Citri Rettculatae Pericarpium, Cyperi Rhizoma, Salviae Miltiorrhizae Radix et Rhizoma, Epimedii Folium, Atractylodis Macrocephalae Rhizoma, Morindae Officinalis Radix, Gleditsiae Spina, Acori Tatarinowii Rhizoma", etc. Potential prescriptions were "Hordei Fructus Germinatus, Setariae Fructus Germinatus, Sargentodoxae Caulis, Puerariae Lobatae Radix, Leonuri Fructus" and so on.Conclusion:The treatment of PCOS with TCM compounds with national patents mainly focuses on drying dampness and strengthening the spleen, tonifying kidney yang and nourishing kidney yin, promoting blood circulation.