Study on the Mechanism of TCM Prevention and Treatment of Liver Fibrosis Based on Autophagy / 世界科学技术-中医药现代化

ABSTRACT

Hepatic fibrosis(HF)is a common pathological process of many chronic liver diseases,and it is also the early reversible stage of cirrhosis.To prevent or reverse hepatic fibrosis is the key to reduce the occurrence of liver cirrhosis and liver cancer.The development of hepatic fibrosis is a complex and dynamic process involving multiple cellulars and molecular mechanisms.More and more studies have shown that dysfunction of autophagy may be an important factor leading to the progression of HF.In recent years,researchers have begun to look for drugs that can reverse HF by regulating autophagy.With the depth of study,TCM continues to make new breakthroughs in the prevention and treatment of liver fibrosis.More and more studies have confirmed that TCM can play a role in the treatment of HF by intervening in autophagy,and its effects can be summarized into two aspects:promoting autophagy(filling its deficiency)and inhibiting autophagy(damaging its excess),and finally restoring the balance of autophagy microenvironment.Thus,it has an anti-fibrosis effect.