Research progress of endothelial injury after hematopoietic stem cell transplantation in children / 中华实用儿科临床杂志

ABSTRACT

Hematopoietic stem cell transplantation (HSCT) in children may lead to endothelial cell activation, and the induction of procoagulant, proinflammatory, and proapoptotic mediators, resulting in endothelial cell dysfunction and injury, as well as life-threatening complications.An effective management of endothelial cell activation, injury, and dysfunction is important for improving outcomes after HSCT.This article reviews the recent advances in the epidemiological features, pathogenesis and treatment of veno-occlusive disease/sinusoidal obstruction syndrome and transplant-related thrombotic microangiopathy after HSCT.