Expression and significance of Bcl-2 and S100A6 in human uterine smooth muscle tumors / 中国现代医生

ABSTRACT

Objective To investigate the expression and meaning of Bcl-2 and S100A6 protein in human uterine smooth muscle tumors. Methods Immunohistochemical technique was used to detect the Bcl-2 and S100A6 protein ex-pressions:30 usual leiomyoma (UL),10 leiomyosarcoma (LMS) and 30 cellular leiomyoma (CL). Results The positive Bcl-2 protein expression rate of UL and CL was apparently higher than that of LMS (P<0.05),the Bcl-2 protein ex-pression were statistical difference in UL and CL; the positive S100A6 protein expression rate of LMS was apparently higher than that of UL(P<0.05),the positive S100A6 protein expression rate of LMS was apparently higher than that of CL(P<0.05). Conclusion The expression of Bcl-2 or S100A6 protein may play an important role in the occurrence and development of human uterine smooth muscie tumors.