Sulindac Prevents Esophageal Adenocarcinomas Induced by Gastroduodenal Reflux in Rats
Yonsei Medical Journal
; : 1020-1027, 2007.
Article
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| WPRIM
| ID: wpr-154647
Biblioteca responsable:
WPRO
ABSTRACT
PURPOSE:
It is known that cyclooxygenase (COX)-2 expression is increased in Barrett's esophagus and esophageal adenocarcinomas. We studied COX-2 expression and the effect sulindac has on the genesis of Barrett's esophagus and adenocarcinoma in rats undergoing esophagogastroduodenal anastomosis (EGDA). MATERIALS ANDMETHODS:
Fifty-one rats were divided into a control group (n=27), a 500ppm sulindac-treated group (n=15) and 1000 ppm sulindac-treated group (n=9). Randomly selected rats were killed by diethyl ether inhalation at 20 and 40 weeks after surgery.RESULTS:
At 40 weeks, rats treated with 1000 ppm sulindac showed narrower esophageal diameter and milder inflammation than the control rats. At 40 weeks, the incidence of Barrett's esophagus was similar between control and sulindac-treated groups, but the incidence of adenocarcinoma was significantly lower in the 1000ppm sulindac-treated group than either the control or 500 ppm sulindac-treated groups. COX-2 was significantly increased in the lower esophagus of control rats killed at 40 weeks. Cyclin D1 expression was negligible in the sulindac- treated group compared with the control group.CONCLUSION:
We suggest that the chemopreventive effect of sulindac is related to decreased COX-2 and cyclin D1 expression, which may be influenced by reduced inflammation.Palabras clave
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Banco de datos:
WPRIM
Asunto principal:
Esófago de Barrett
/
Neoplasias Esofágicas
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Inmunohistoquímica
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Adenocarcinoma
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Sulindac
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Western Blotting
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Ratas Sprague-Dawley
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Antígeno Nuclear de Célula en Proliferación
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Ciclina D1
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Reflujo Duodenogástrico
Límite:
Animals
Idioma:
En
Año:
2007
Tipo del documento:
Article