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Change of Gastric Emptying With Chewing Gum: Evaluation Using a Continuous Real-Time 13C Breath Test (BreathID System)
Article en En | WPRIM | ID: wpr-218794
Biblioteca responsable: WPRO
ABSTRACT
BACKGROUND/AIMS: There are few reports on the correlation between chewing gum and the gastrointestinal functions. But previous report showed use of chewing gum to be an effective method for controlling gastrointestinal symptoms. The aim of this study was to determine the correlation between chewing gum and gastric emptying using the continuous real time 13C breath test (BreathID system). METHODS: Ten healthy male volunteers participated in this randomized, 2-way crossover study. The subjects fasted overnight and were randomly assigned to chewing gum (Xylish, 2-3/1 tablet) for an hour following intake of a test meal (200 kcal/200 mL) or intake of the test meal alone. Gastric emptying was monitored for 4 hours after administration of the test meal by the 13C-acetic acid breath test performed continually using the BreathID system. RESULTS: No significant differences in the calculated parameters, namely, T1/2 (median, 111.82 vs 109.26 minutes; P = 0.575), Tlag (median, 53.28 vs 56.53 minutes; P = 0.333), gastric emptying coefficient (median, 3.58 vs 3.65; P = 0.285), regression-estimated constant beta (median, 1.85 vs 1.80; P = 0.575) and regression-estimated constant kappa (median, 0.61 vs 0.62; P = 0.959) were observed between the test meal alone group and the test meal and chewing gum group. CONCLUSIONS: This study showed that chewing gum had no effect on the rate of gastric emptying. Therefore, since chewing gum did not enhance the speed of gastric emptying, it may ameliorate gastrointestinal symptoms through other mechanisms, such as saliva and autonomic nervous system.
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Texto completo: 1 Banco de datos: WPRIM Asunto principal: Saliva / Sistema Nervioso Autónomo / Pruebas Respiratorias / Goma de Mascar / Estudios Cruzados / Comidas / Vaciamiento Gástrico / Masticación Tipo de estudio: Clinical_trials Límite: Humans / Male Idioma: En Año: 2011 Tipo del documento: Article
Texto completo: 1 Banco de datos: WPRIM Asunto principal: Saliva / Sistema Nervioso Autónomo / Pruebas Respiratorias / Goma de Mascar / Estudios Cruzados / Comidas / Vaciamiento Gástrico / Masticación Tipo de estudio: Clinical_trials Límite: Humans / Male Idioma: En Año: 2011 Tipo del documento: Article