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Transgenic animals bioreactors / 生物工程学报
Chinese Journal of Biotechnology ; (12): 144-148, 2002.
Article en Zh | WPRIM | ID: wpr-231360
Biblioteca responsable: WPRO
ABSTRACT
The production of human recombinant proteins in milk of transgenic farm animals offers a safe, very cost-effective source of commercially important proteins that cannot be produced as efficiently in adequate quantities by other methods. This review has summarized the current status of gene selection, vector construct, transgenic methods, economics, and obvious potential in transgenic animals bioreactors. Recently, a more powerful approach was adopted in the transgenic animals founded on the application of nuclear transfer. As we will illustrate, this strategy presents a breakthrough in the overall efficiency of generating transgenic farm animals, product consistency, and time of product development. The successful adaptation of Cre-/lox P-mediated site-specific DNA recombination systems in farm animals will offer unprecedented possibilities for generating transgenic animals.
Asunto(s)
Texto completo: 1 Banco de datos: WPRIM Asunto principal: Mama / Animales Modificados Genéticamente / Expresión Génica / Trasplante de Células / Reactores Biológicos / Metabolismo Límite: Animals / Humans Idioma: Zh Año: 2002 Tipo del documento: Article
Texto completo: 1 Banco de datos: WPRIM Asunto principal: Mama / Animales Modificados Genéticamente / Expresión Génica / Trasplante de Células / Reactores Biológicos / Metabolismo Límite: Animals / Humans Idioma: Zh Año: 2002 Tipo del documento: Article