Effect of Jinguo Weikang Capsule on proto-oncogene expression of gastric mucosa in rats with gastric precancerous lesions / 中国结合医学杂志
Chinese journal of integrative medicine
; (12): 212-216, 2008.
Article
en En
| WPRIM
| ID: wpr-236264
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of Jinguo Weikang Capsule [see text] on the gene expression of H-ras, epidermal growth factor receptor (EGFR), P53 and C-myc of the gastric mucosa in rats with gastric precancerous lesions, and to investigate the action mechanism of JWC on gastric precancerous lesions.</p><p><b>METHODS</b>A rat model with paratypical proliferation of the gastric epithelium mucosa was established by using 60Co irradiation. Rats were divided into the normal group, model group, high-, medium-, low-dose JWC treatment groups, and the vitacoenzyme control group, and were treated for 30 days. The expression of H-ras, EGFR, P53 and C-myc genes of the gastric mucosa was detected by using immunohistochemical methods.</p><p><b>RESULTS</b>The expression and over-expression rates of H-ras, EGFR, P53 and C-myc gene in the high-and medium-dose JWC treatment groups were significantly lower (P<0.05) as compared with those of the model group.</p><p><b>CONCLUSION</b>JWC can inhibit the expression of the H-ras, EGFR, P53 and C-myc genes expression of the gastric mucosa in rats, which may be one of mechanisms involved in suppressing or reversing gastric carcinogenesis.</p>
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1
Banco de datos:
WPRIM
Asunto principal:
Patología
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Farmacología
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Lesiones Precancerosas
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Medicamentos Herbarios Chinos
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Inmunohistoquímica
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Regulación Neoplásica de la Expresión Génica
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Proteína p53 Supresora de Tumor
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Proteínas Proto-Oncogénicas c-myc
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Proteínas Proto-Oncogénicas
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Ratas Sprague-Dawley
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Año:
2008
Tipo del documento:
Article