Big data: the progress and applications of antibody repertoire sequencing / 南方医科大学学报
Journal of Southern Medical University
; (12): 463-467, 2015.
Article
en Zh
| WPRIM
| ID: wpr-239155
Biblioteca responsable:
WPRO
ABSTRACT
Antibody, the major effector in adaptive immunity, plays key roles in protective and pathogenic immune responses. Integrative analyses of antibody development, differentiation, and maturation promote the research in immune mechanism, vaccine design, and therapies for autoimmune disorders. The development of next generation sequencing technologies has enabled large-scale characterization of functional antibody repertoires. With the advantages of next generation sequencing, antibody and antibody repertoire analysis have been successfully used in identification of HIV-1-broadly neutralizing antibodies, design of rationale structure-based vaccine, and development of immunology. With increasing sequence length and precision, improvement of experimental protocols and bioinformatics analyses, and development of single cell sequencing technology, antibody repertoire sequencing will expedite the research in antibody-related immune response, and thus facilitates vaccine design for infectious diseases, clinical diagnosis and interference of autoimmune diseases. This review introduces the technologies, progresses, applications, and caveats of antibody repertoire sequencing.
Texto completo:
1
Banco de datos:
WPRIM
Asunto principal:
Vacunas
/
Química
/
VIH-1
/
Anticuerpos Neutralizantes
/
Secuenciación de Nucleótidos de Alto Rendimiento
/
Anticuerpos
/
Formación de Anticuerpos
Tipo de estudio:
Guideline
Límite:
Humans
Idioma:
Zh
Año:
2015
Tipo del documento:
Article