Relationship between ACE gene insertion or deletion polymorphism and left ventricular mass in newborns admitted to the neonatal intensive care unit / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 767-770, 2010.
Article
en Zh
| WPRIM
| ID: wpr-286991
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the relationship between angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and left ventricular mass (LVM) in newborns admitted to the neonatal intensive care unit (NICU).</p><p><b>METHODS</b>Seventy-two newborns admitted to the NICU were enrolled. ACE genotypes were determined by genomic DNA which was isolated from heel-prick blood. Disease status of the newborns was evaluated by the Neonatal Critical Score (draft) on postnatal day 1. LVM and LVM index (LVMI) were evaluated by echocardiography on postnatal days 1-3.</p><p><b>RESULTS</b>DD genotype was identified in 11 cases, ID genotype in 31 cases, and II genotype in 30 cases. There were no significant differences in clinical characteristics, critical score and body measurements in newborns with different genotypes. The DD genotype group showed significantly lower LVMI than the group with ID+II genotypes (29±4 g/m2 vs 35±8 g/m2; P<0.05).</p><p><b>CONCLUSIONS</b>ACE gene polymorphism is associated with the LVMI in newborns admitted to the NICU. The LVMI of DD genotype carriers is significantly lower than that of ID+II genotypes carriers, which suggests that D allele may be associated with the growth and development of left ventricular.</p>
Texto completo:
1
Banco de datos:
WPRIM
Asunto principal:
Polimorfismo Genético
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Diagnóstico por Imagen
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Ecocardiografía
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Unidades de Cuidado Intensivo Neonatal
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Mutagénesis Insercional
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Eliminación de Gen
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Peptidil-Dipeptidasa A
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Genética
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Genotipo
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Ventrículos Cardíacos
Tipo de estudio:
Diagnostic_studies
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Prognostic_studies
Límite:
Female
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Humans
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Male
Idioma:
Zh
Año:
2010
Tipo del documento:
Article