Improving the dissolution rate of poorly water-soluble resveratrol by the ordered mesoporous silica / 药学学报
Acta Pharmaceutica Sinica
; (12): 239-243, 2012.
Article
en Zh
| WPRIM
| ID: wpr-323051
Biblioteca responsable:
WPRO
ABSTRACT
The aim of this study is to synthesize the ordered mesoporous silica (OMS) as drug carrier to improve release property of insoluble drug and investigate the dissolution profile of insoluble drug from the porous carrier. The OMS was obtained by using cetyltrimethyl ammonium bromide as the template and resveratrol was selected as the model drug. The resveratrol-loaded OMS (Res-OMS) were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), N2 adsorption-desorption, X-ray diffraction (XRD) and FT-IR spectroscopy. In vitro drug release behavior was also investigated. It was found that the synthesized OMS showed a large surface area, a narrow pore size distribution and an important mesoporosity associated to hexagonally organized channels. Compared with physical mixture and crystalline powder, resveratrol was in amorphous or molecular form after loading into OMS. The release rate ofresveratrol from drug-loaded OMS was significantly increased suggesting the great potential application of OMS for the formulation of poorly soluble drugs.
Texto completo:
1
Banco de datos:
WPRIM
Asunto principal:
Solubilidad
/
Estilbenos
/
Difracción de Rayos X
/
Portadores de Fármacos
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Microscopía Electrónica de Rastreo
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Química
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Porosidad
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Sistemas de Liberación de Medicamentos
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Espectroscopía Infrarroja por Transformada de Fourier
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Dióxido de Silicio
Idioma:
Zh
Año:
2012
Tipo del documento:
Article