Analysis on synergistic action between estrogen, progesterone and human papillomaviruses in cervical cancer / 中华流行病学杂志
Chinese Journal of Epidemiology
; (12): 370-373, 2005.
Article
en Zh
| WPRIM
| ID: wpr-331874
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the effects of estrogen (E(2)) and progesterone (P) on cervical cancer and the synergistic action between estrogen, progesterone and human papillomaviruses (HPV).</p><p><b>METHODS</b>Hoted-start polymerase chain reaction (HS-PCR) was used to detect HPVs, HPV16 and ELISA was used to assay E(2) and P on 141 cases with cervical cancer and on 129 healthy controls.</p><p><b>RESULTS</b>Positive rates of HPVs and HPV16 were 75.2% and 46.8% respectively in cervical cancer group, significantly higher than that in controls. Levels of estrogen and progesterone in case group were significantly higher than that in controls and a dose-responded relationship between the levels of estrogen and cervical cancer was revealed. Estrogen and HPV showed an additive interaction in the development of cervical cancer.</p><p><b>CONCLUSION</b>HPV16 infection played a principal role in the development of cervical cancer. The high levels of entogenous estrogen could increase the risk of cervical cancer and might serve as a cofactor in the development of HPV-induced cervical cancer.</p>
Texto completo:
1
Banco de datos:
WPRIM
Asunto principal:
Progesterona
/
Virología
/
Sangre
/
ADN Viral
/
Ensayo de Inmunoadsorción Enzimática
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Neoplasias del Cuello Uterino
/
China
/
Reacción en Cadena de la Polimerasa
/
Epidemiología
/
Factores de Riesgo
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Límite:
Adult
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Aged
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Female
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Humans
País como asunto:
Asia
Idioma:
Zh
Año:
2005
Tipo del documento:
Article