Effects of calcium on ability of learning and memory in rats exposed to low level lead before and after birth / 浙江大学学报·医学版

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the effects of calcium on learning and memory ability of rats exposed to low level lead before and after birth.</p><p><b>METHODS</b>Wistar dam rats were randomly divided into normal group, lead-contaminated group and lead with Ca group. Corresponding food and water were given to pregnant rats from d 15 of gestation and to young rats till 7 w after birth. The weight of brain and hippocampus, blood lead content, serum calcium content, learning and memory ability of young rats were tested.</p><p><b>RESULT</b>The blood lead concentrations: lead-contaminated group was the highest, lead with Ca group the second and normal group the lowest. Serum calcium concentrations: normal group and lead with Ca group were both higher than lead contaminated group. Ability of learning and memory: lead with Ca group was better than lead-contaminated group, but poorer than normal group. No differences were found upon the weight of brain and hippocampus in all groups.</p><p><b>CONCLUSION</b>A minilaparotomy approach for curative resection of rectal cancer may be an ideal alternative approach to conventional laparotomy.</p>