The systematic evaluation of establishing spinal cord transection model in rats / 中国组织工程研究
Chinese Journal of Tissue Engineering Research
; (53): 6553-6560, 2015.
Article
en Zh
| WPRIM
| ID: wpr-478217
Biblioteca responsable:
WPRO
ABSTRACT
BACKGROUND:
Establishing a highly successful, safe, reliable standard spinal cord transection model is the precondition of studying spinal cord injury repair.OBJECTIVE:
To evaluate the value of preparing spinal cord transection model in rats and the effects of laminectomy on spinal cord.METHODS:
We searched the randomized controled trials involving rat models of spinal cord transection in the databases of PubMed, CNKI, VIP and WanFang. RESULTS ANDCONCLUSION:
11 randomized controled trials (RCTs) met the inclusion criteria (two in English, 9 in Chinese), and a total of 394 rats were included in the study. There were significant differences in the lower limb motor function scores (BBB scores) within 1-6 weeks after injury (WMD=-12.86, 95%CI-16.10 to-9.62,P < 0.01) and electrophysiological indices within 4 weeks after injury (WMD=15.36, 95%CI 11.36 to 19.36,P < 0.01) between spinal cord hemisection group and laminectomy group. The BBB scores after 6 weeks were not significantly different between these two groups (WMD=-10.28; 95%CI-24.20 to 3.64;P=0.15). There were significant differences in the lower limb motor function scores (BBB scores) within 1-6 weeks after injury (WMD=
Texto completo:
1
Banco de datos:
WPRIM
Tipo de estudio:
Clinical_trials
/
Prognostic_studies
Idioma:
Zh
Año:
2015
Tipo del documento:
Article