Effects of naringin on growth and COX-2 expressions in human cervical cancer HeLa cell line / 中国免疫学杂志
Chinese Journal of Immunology
; (12): 1200-1203, 2016.
Article
en Zh
| WPRIM
| ID: wpr-495086
Biblioteca responsable:
WPRO
ABSTRACT
Objective: To study the effect of naringin on human cervical cancer HeLa cell line and its related mechanism.Methods:HeLa cells were cultured in vitro in the presence of different concentration naringin .The method of MTT was used to detect the growth of HeLa cell in 24 h, 48 , 72 h.Apoptotic cells were observed by Hoechst 33258 staining.The protein expressions of COX-2 in SCL-12 cells were analyzed by Western blot .Results: The inhibition ratio of the cell growth in middle dose group and high dose group significantly higher than control group ( P0.05).The apoptosis ratio of the cell growth in middle dose group and high dose group significantly higher than control group( P0.05 ) .The expression of COX-2 was significantly decreased in middle dose group and high dose group .Conclusion: Naringin plays a central role in the apoptosis of the human cervical cancer HeLa cell line ,which may be related to the expression of COX-2.
Texto completo:
1
Banco de datos:
WPRIM
Idioma:
Zh
Año:
2016
Tipo del documento:
Article