Effect of intensive atorvastatin therapy on B7-H4 in peripheral blood monocytes of patients with unstable angina undergoing percutaneous coronary intervention / 实用医学杂志
The Journal of Practical Medicine
; (24): 975-978, 2017.
Article
en Zh
| WPRIM
| ID: wpr-512600
Biblioteca responsable:
WPRO
ABSTRACT
Objective To investigate the intensive atorvastatin therapy on B7-H4 in peripheral blood monocytes of patients with unstable angina PCI undergoing percutaneous coronary intervention. Methods 80 patients with unstable angina were randomized to pretreatment with intensive dose (80 mg/day ,n = 40) and conventional dose(20 mg/day,n=40)of atorvastatin. Peripheral blood were subsequently obtained prior to PCI,and 18 ~ 24 h after PCI. Peripheral blood serum level of IL-4,IL-10 and IFN-γ were quantified using enzyme-linked immunosorbent assays. Fluorescence-based quantitative real-time PCR was used to measure levels of periph-eral blood monocytes B7-H4 mRNA. Results Levels of IL-10 ,sB7-H4 and B7-H4 mRNA increased in patients of both groups after PCI. The increase in intensive dose group is more significant (P < 0.05). IL-4 and IFN-γ decreased in patients of both groups after PCI. The decrease in intensive dose group is more significant (P <0.05). Conclusion Intensive dose atorvastatin treatment improve post-PCI immune inflammation in patients with unstable angina,possibly by promoting the expression of B7-H4 in peripheral blood monocytes.
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Banco de datos:
WPRIM
Tipo de estudio:
Clinical_trials
Idioma:
Zh
Año:
2017
Tipo del documento:
Article