Influence of pdx1 gene and its epigenetic modification upon pancreatic development and β-cell function / 国际儿科学杂志

ABSTRACT

The development of embryo has close relation with the occurrence of type 2 diabetes in adulthood and is attracting increasingly more attention recently. Pancreatic and duodenal homeobox 1 ( pdx1 )expresses in all stages of β-cell development and in mature β cells. As a transcription factor,pdx1 plays a critical role in the formation of whole pancreas,especially in the development and function of β-cell in fetal period,and it is also necessary for the maintenance of mature β-cell function. However, changes in epigenetic modification can alter the expression of pdx1, and then influence pancreatic development and β-cell function . We will make a summary about pdx1 gene structure, function, regulation ,epigenetic modification and so on.