Research progress of p38 mitogen-activated protein kinase signaling pathway in pulmonary diseases / 复旦学报（医学版）

ABSTRACT

P38 mitogen-activated protein kinase (p38 MAPK) signaling pathway is involved in many processes such as cell proliferation,differentiation,survival and inflammatory cytokine production and plays an important role in inflammation,cell proliferation,apoptosis,epithelial-mesenchymal transitions and tumor invasion which occur in pulmonary diseases.Moreover,there have been some clinical studies on p38 MAPK inhibitors in chronic obstructive pulmonary disease.p38 MAPK signaling pathway could be a therapeutical target for respiratory diseases in the future.This article summarizes recent researches on p38 MAPK in pulmonary diseases.